Our results indicate that hAESCs injection reduced amyloid plaques caused by reduced BACE activity. In this study, we found that intracerebral injection of hAESCs alleviated cognitive impairment in a Tg2576 mouse model of AD. Finally, beta-secretase (BACE) activity was significantly decreased in Tg mice at 60 min after hAESCs injection. Furthermore, Congo red staining revealed that hAESCs injection reduced the number of amyloid plaques present in the brains of Tg mice. In the Y-maze test, hAESC-treated Tg mice exhibited significantly higher rate of spontaneous alteration than vehicle-treated Tg mice, while the total number of arm entries did not differ between the groups. In the Morris water maze test, hAESC-treated Tg mice exhibited significantly shorter escape latencies than vehicle-treated Tg mice. Tg2576 transgenic (Tg) mice underwent behavioral tests, namely the Morris water maze and Y-maze tests, to assess their cognitive function.

In this study, we aimed to elucidate the therapeutic effects of human amniotic epithelial stem cells (hAESCs) in a transgenic mouse model of AD. However, there is currently no cure for AD. AD is the most common cause of dementia among older people. To view the papers in pdf format, click on the 'PDF Full-text' link, and use the free Adobe Reader to open them.Īlzheimer’s disease (AD), a progressive neurodegenerative disorder, is characterized clinically by cognitive decline and pathologically by the development of amyloid plaques.

PDF is the official format for papers published in both, html and pdf forms.You may sign up for e-mail alerts to receive table of contents of newly released issues.Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.Thus, processes as different as the inactivation of channel K + currents or the assembly of clusters from individual KcsA channels depend on such lipid binding. Interestingly, most such effects have in common the initial binding of anionic lipids to two key arginine residues located at non-annular lipid binding sites on the channel protein. Here, we have reviewed the multiple alterations lipids cause on the prokaryotic KcsA, possibly the best studied ion channel undergoing lipid modulation.

Many integral membrane proteins, including ion channels, are modulated structurally and functionally by the surrounding lipids, but the molecular mechanisms behind it remain largely unknown.

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